Combined use of stereospecific deuteration, NMR, distance geometry, and energy minimization for the conformational analysis of the highly .delta. opioid receptor selective peptide [D-Pen2,D-Pen5]enkephalin

@article{Mosberg1990CombinedUO,
  title={Combined use of stereospecific deuteration, NMR, distance geometry, and energy minimization for the conformational analysis of the highly .delta. opioid receptor selective peptide [D-Pen2,D-Pen5]enkephalin},
  author={H. Mosberg and K. Sobczyk-Kojiro and P. Subramanian and G. Crippen and K. Ramalingam and R. Woodard},
  journal={Journal of the American Chemical Society},
  year={1990},
  volume={112},
  pages={822-829}
}
  • H. Mosberg, K. Sobczyk-Kojiro, +3 authors R. Woodard
  • Published 1990
  • Chemistry
  • Journal of the American Chemical Society
  • Comparison of 'H and "C NMR parameters for the cyclic, conformationally restricted, 6 opioid receptor selective enkephalin analogue Tyr-D-Pen-Gly-Phe-WPen ((~-Pen~,~-Pen~)enkephalin, DPDPE) in aqueous versus dimethyl sulfoxide (DMSO) solution indicates that this peptide adopts similar conformations in these solvents. This suggestion that the conformation of DPDPE is relatively environment independent allows conclusions regarding the receptor-bound conformation of this peptide to be drawn from… CONTINUE READING
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