Combined use of Paracoccidioides brasiliensis recombinant 27-kilodalton and purified 87-kilodalton antigens in an enzyme-linked immunosorbent assay for serodiagnosis of paracoccidioidomycosis.

@article{Dez2003CombinedUO,
  title={Combined use of Paracoccidioides brasiliensis recombinant 27-kilodalton and purified 87-kilodalton antigens in an enzyme-linked immunosorbent assay for serodiagnosis of paracoccidioidomycosis.},
  author={Soraya D{\'i}ez and Beatriz L G{\'o}mez and Juan G Mcewen and {\'A}ngela Restrepo and Rod J. Hay and Andrew John Hamilton},
  journal={Journal of clinical microbiology},
  year={2003},
  volume={41 4},
  pages={1536-42}
}
The diagnosis of paracoccidioidomycosis (PCM) has relied on the identification of the host's humoral response by using a variety of immunological methods, such as complement fixation and immunodiffusion. Although these approaches are useful, historically their sensitivity and specificity have often been compromised by the use of complex mixtures of undefined antigens. The use of combinations of purified, well-characterized antigens appears preferable and may yield optimum results. Accordingly… CONTINUE READING
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