Combined use of COX-1 and VEGF immunohistochemistry refines the histopathologic prognosis of renal cell carcinoma.

@article{Osman2015CombinedUO,
  title={Combined use of COX-1 and VEGF immunohistochemistry refines the histopathologic prognosis of renal cell carcinoma.},
  author={Wesam Mohamed Osman and Nermeen Salah Youssef},
  journal={International journal of clinical and experimental pathology},
  year={2015},
  volume={8 7},
  pages={8165-77}
}
The course of RCC is asymptomatic, resulting in 25-30% of patients presenting with metastatic disease at time of diagnosis. The development of novel agents targeting angiogenesis and signal transduction pathways has improved patient outcomes. Role of cyclooxygenase in cancer development has been the subject of close scrutiny. COX-1 has been recognized to be involved in regulation of angiogenesis. To date, no immunohistochemical studies have been performed to assess the possible association… CONTINUE READING