Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

  title={Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging},
  author={I. Varela and S. Pereira and A. Ugalde and C. Navarro and M. F. Su{\'a}rez and P. Cau and J. Cadi{\~n}anos and Fernando G. Osorio and N. Foray and J. Cobo and F. Carlos and N. Levy and J. Freije and C. López-Otı́n},
  journal={Nature Medicine},
  • I. Varela, S. Pereira, +11 authors C. López-Otı́n
  • Published 2008
  • Biology, Medicine
  • Nature Medicine
  • Several human progerias, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by the accumulation at the nuclear envelope of farnesylated forms of truncated prelamin A, a protein that is also altered during normal aging. Previous studies in cells from individuals with HGPS have shown that farnesyltransferase inhibitors (FTIs) improve nuclear abnormalities associated with prelamin A accumulation, suggesting that these compounds could represent a therapeutic approach for this… CONTINUE READING
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