Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

@article{Varela2008CombinedTW,
  title={Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging},
  author={Ignacio Varela and Sandrine Pereira and Alejandro Pi{\~n}eiro Ugalde and Claire Laure Navarro and Mar{\'i}a Fernanda Su{\'a}rez and Pierre Cau and Juan Cadi{\~n}anos and Fernando G. Osorio and Nicolas Foray and J. Aedo Cobo and F{\'e}lix de Carlos and Nicolas L{\'e}vy and Jos{\'e} M P Freije and Carlos L{\'o}pez-Ot{\'i}n},
  journal={Nature Medicine},
  year={2008},
  volume={14},
  pages={767-772}
}
Several human progerias, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by the accumulation at the nuclear envelope of farnesylated forms of truncated prelamin A, a protein that is also altered during normal aging. Previous studies in cells from individuals with HGPS have shown that farnesyltransferase inhibitors (FTIs) improve nuclear abnormalities associated with prelamin A accumulation, suggesting that these compounds could represent a therapeutic approach for this… CONTINUE READING
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