Combined treatment with galanthaminium bromide, a new cholinesterase inhibitor, and RS 67333, a partial agonist of 5-HT4 receptors, enhances place and object recognition in young adult and old rats.

@article{Lamirault2003CombinedTW,
  title={Combined treatment with galanthaminium bromide, a new cholinesterase inhibitor, and RS 67333, a partial agonist of 5-HT4 receptors, enhances place and object recognition in young adult and old rats.},
  author={La{\"e}titia Lamirault and Catherine Guillou and Claude Thal and Herv{\'e} Simon},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2003},
  volume={27 1},
  pages={185-95}
}
The present study was designed to investigate whether a combination of a new acetylcholinesterase inhibitor we have synthesized, galanthaminium bromide, and an agonist of 5-hydroxytryptamine(4) receptors, RS 67333, at doses ineffective alone, improves performance in tasks involving place and object recognition memory. Dose responses of each compound were determined in order to select doses without effect alone. Accordingly, young adult rats were injected intraperitoneally with galanthaminium… CONTINUE READING
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