Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in beta-phenylethylamine.

@article{Kitaichi2010CombinedTW,
  title={Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in beta-phenylethylamine.},
  author={Yuji Kitaichi and Takeshi Inoue and Shin Nakagawa and Shuken Boku and Takeshi Izumi and Tsukasa Koyama},
  journal={European journal of pharmacology},
  year={2010},
  volume={637 1-3},
  pages={77-82}
}
Monoamine oxidase inhibitors (MAO inhibitors) have been widely used as antidepressants. However, it remains unclear whether a difference exists between non-selective MAO inhibitors and selective MAO-A inhibitors in terms of their antidepressant effects. Using in vivo microdialysis methods, we measured extracellular noradrenaline and serotonin levels following administration of Ro 41-1049, a reversible MAO-A inhibitor and/or lazabemide, a reversible MAO-B inhibitor in the medial prefrontal… CONTINUE READING
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