Combined treatment with GH, insulin, and indomethacin alleviates cancer cachexia in a mouse model.

@article{Chen2011CombinedTW,
  title={Combined treatment with GH, insulin, and indomethacin alleviates cancer cachexia in a mouse model.},
  author={Si-zeng Chen and Zhengguo Qiu},
  journal={The Journal of endocrinology},
  year={2011},
  volume={208 2},
  pages={
          131-6
        }
}
Cancer-induced cachexia involves weight loss, catabolic activity, and inflammation. We have evaluated the effects of various treatments (GH, insulin (INS), indomethacin (IND), and all possible combinations) on cancer cachexia in a mouse model. BALB/c mice that were implanted with colon-26 adenocarcinoma developed cachexia in 9 days. Body weight, tumor volume, tumor-free weight, inflammatory cytokines (tumor necrosis factor-α (TNF-α), interleukin 6 (IL6)), and nutritional markers (glucose (Glu… Expand
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