Combined thiazolidinedione–metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle

@article{Temofonte2008CombinedTT,
  title={Combined thiazolidinedione–metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle},
  author={N. Temofonte and Mini P. Sajan and Subasinghe Nimal and Tina E. Pastoor and Cecilia Fumero and L. Casaubon and Jennifer Powe and Mary L. Standaert and R. V. Farese},
  journal={Diabetologia},
  year={2008},
  volume={52},
  pages={60-64}
}
Aims/hypothesesInsulin-stimulated glucose transport in muscle is impaired in type 2 diabetes, presumably reflecting reduced activation of atypical protein kinase C (aPKC) and protein kinase B (PKB/Akt). As previously shown, reductions in aPKC activation are seen at sub-maximal and maximal insulin stimulation, reductions in PKB activation are best seen at sub-maximal insulin stimulation and aPKC reductions at maximal insulin are partly improved by thiazolidinedione or metformin treatment… CONTINUE READING

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