Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial.

@article{Appelhof2005CombinedTW,
  title={Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial.},
  author={Bente C Appelhof and Eric Fliers and Ellie M Wekking and Aart H. Schene and Jochanan Huyser and Jan G. P. Tijssen and Erik Endert and H. C. P. M. van Weert and Wilmar Maarten Wiersinga},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 5},
  pages={2666-74}
}
Controversy remains about the value of combined treatment with levothyroxine (LT4) and liothyronine (LT3), compared with LT4 alone in primary hypothyroidism. We compared combined treatment with LT4 and LT3 in a ratio of 5:1 or 10:1 with LT4 monotherapy. We conducted a double-blind, randomized, controlled trial in 141 patients (18-70 yr old) with primary autoimmune hypothyroidism, recruited via general practitioners. Inclusion criteria included: LT4 treatment for 6 months or more, a stable dose… CONTINUE READING