Combined targeting of mTOR and AKT is an effective strategy for basal-like breast cancer in patient-derived xenograft models.

@article{Xu2013CombinedTO,
  title={Combined targeting of mTOR and AKT is an effective strategy for basal-like breast cancer in patient-derived xenograft models.},
  author={Siguang Xu and Shunqiang Li and Zhanfang Guo and Jingqin Luo and Matthew J. Ellis and Cynthia X. Ma},
  journal={Molecular cancer therapeutics},
  year={2013},
  volume={12 8},
  pages={1665-75}
}
Basal-like breast cancer is an aggressive disease for which targeted therapies are lacking. Recent studies showed that basal-like breast cancer is frequently associated with an increased activity of the phosphatidylinositol 3-kinase (PI3K) pathway, which is critical for cell growth, survival, and angiogenesis. To investigate the therapeutic potential of PI3K pathway inhibition in the treatment of basal-like breast cancer, we evaluated the antitumor effect of the mTOR inhibitor MK-8669 and AKT… CONTINUE READING
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