Combined systemic administration of the glycine/NMDA receptor antagonist, (+)-HA966 and morphine attenuates pain-related behaviour in a rat model of trigeminal neuropathic pain

@article{Christensen1999CombinedSA,
  title={Combined systemic administration of the glycine/NMDA receptor antagonist, (+)-HA966 and morphine attenuates pain-related behaviour in a rat model of trigeminal neuropathic pain},
  author={Dennis Christensen and Mich{\'e}le Gautron and Gis{\'e}le Guilbaud and Val{\'e}rie Kayser},
  journal={PAIN{\textregistered}},
  year={1999},
  volume={83},
  pages={433-440}
}
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48 Citations
Highly Influential Citations
5
Background Citations
15
Methods Citations
3
Results Citations
4

48 Citations

Complete Prevention but Stimulus-dependent Reversion of Morphine Tolerance by the Glycine/NMDA Receptor Antagonist (+)-HA966 in Neuropathic Rats

The ability of the glycine/ N-methyl-D-aspartate receptor antagonist (+)-HA966 to modify morphine tolerance in a rat model of neuropathic pain was studied to prevent the development of tolerance and reverse established morphine tolerance.

N-methyl-D-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain.

The 5-HT(1A) receptor agonist F 13640 attenuates mechanical allodynia in a rat model of trigeminal neuropathic pain.

Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process

The antimigraine 5‐HT1B/1D receptor agonists, sumatriptan, zolmitriptan and dihydroergotamine, attenuate pain‐related behaviour in a rat model of trigeminal neuropathic pain

The rationale for exploring the clinical efficacy of brain penetrant 5‐HT1B/1D receptor agonists as analgesics to reduce certain types of trigeminal neuropathic pain in humans is supported.

Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons.

Additive Effect of Combined Application of Magnesium and MK-801 on Analgesic Action of Morphine

If magnesium sulphate and MK-801 were applied concomitantly, a clear additive effect on the analgesic action of morphine occurred in both models of pain.

Effect of gabapentin and lamotrigine on mechanical allodynia-like behaviour in a rat model of trigeminal neuropathic pain

Synergistic μ-opioid and 5-HT1A presynaptic inhibition of GABA release in rat periaqueductal gray neurons

Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin‐catabolizing enzymes, are enhanced by (+)‐HA966, a functional NMDA receptor antagonist: a c‐Fos study in the rat spinal cord

References

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The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)‐HA966 in a rat model of peripheral neuropathy

  • D. ChristensenJuhana J. Idänpään‐HeikkiläGisèle GuilbaudValérie Kayser
  • Biology, Medicine
    British journal of pharmacology
  • 1998
The findings suggest that combined administration of antagonists, acting at the glycine site of the NMDA receptor complex and morphine may be a promising approach in the treatment of neuropathic and acute pain.

Pharmacological studies on a rat model of trigeminal neuropathic pain: baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviour

Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy

Potentiation of morphine-induced antinociception in acute spinal rats by the NMDA antagonist dextrorphan

The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive

The induction and maintenance of central sensitization is dependent on N-methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

N-methyl-D-aspartate receptor antagonists potentiate morphine's antinociceptive effect in the rat.

It is suggested that blockade of NMDA receptors enhances the antinociceptive effect of morphine and NMDA antagonists may improve the analgesic efficacy of morphine in the clinic.

Opioids modulate N-methyl-d-aspartic acid (NMDA)-evoked responses of neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis)

Chemically-diverse ligands at the glycine B site coupled to N-methyl-d-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice

NMDA receptor antagonists: interactions with opioids

The N‐methyl‐D‐aspartate (NMDA) receptor for glutamate has been implicated in the generation and maintenance of central (spinal) states of hypersensitivity and the ability of opioids to act presynap‐tically on C‐fibre terminals to reduce transmitter release produces synergistic inhibitions with postsynaptically acting NMDA receptor antagonists.
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