Combined suicide and granulocyte–macrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity

@article{Jones2000CombinedSA,
  title={Combined suicide and granulocyte–macrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity},
  author={Rebecca Jones and Ian M Pope and Anne R Kinsella and Alastair JM Watson and Stephen E Christmas},
  journal={Cancer Gene Therapy},
  year={2000},
  volume={7},
  pages={1519-1528}
}
The use of prodrug-activated (“suicide”) gene therapy has been shown to be effective in inducing tumor regression when only a small proportion of tumor cells contains the suicide gene. These experiments were designed to test whether additional therapeutic benefit may be obtained by stimulating the immune response. Murine MC26 colon carcinoma cells, either untransduced or transduced with genes for herpes simplex virus-1 thymidine kinase (HSV1-TK) or human GM-CSF, were injected subcutaneously… CONTINUE READING
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Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)

Journal of biomedicine & biotechnology • 2003
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