Combined sub-threshold dosages of phenobarbital and low-frequency stimulation effectively reduce seizures in amygdala-kindled rats

@article{Asgari2014CombinedSD,
  title={Combined sub-threshold dosages of phenobarbital and low-frequency stimulation effectively reduce seizures in amygdala-kindled rats},
  author={Azam Asgari and Saeed Semnanian and Nafiseh Atapour and Amir Shojaei and Homeira Moradi and Javad Mirnajafi-zadeh},
  journal={Neurological Sciences},
  year={2014},
  volume={35},
  pages={1255-1260}
}
Low-frequency stimulation (LFS) is a potential therapy utilized in patients who do not achieve satisfactory control of seizures with pharmacological treatments. Here, we investigated the interaction between anticonvulsant effects of LFS and phenobarbital (a commonly used medicine) on amygdala-kindled seizures in rats. Animals were kindled by electrical stimulation of basolateral amygdala in a rapid manner (12 stimulations/day). Fully kindled animals randomly received one of the three treatment… CONTINUE READING
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