Combined statin and niacin therapy remodels the high-density lipoprotein proteome.

@article{Green2008CombinedSA,
  title={Combined statin and niacin therapy remodels the high-density lipoprotein proteome.},
  author={Pattie S. Green and Tom{\'a}{\vs} Vaisar and Subramaniam Pennathur and J Jacob Kulstad and Andrew B Moore and Santica Marcovina and John D. Brunzell and R. Knopp and X Q Zhao and Jay W. Heinecke},
  journal={Circulation},
  year={2008},
  volume={118 12},
  pages={1259-67}
}
BACKGROUND Boosting low high-density lipoprotein (HDL) levels is a current strategy for preventing clinical events that result from cardiovascular disease. We previously showed that HDL(3) of subjects with coronary artery disease is enriched in apolipoprotein E and that the lipoprotein carries a distinct protein cargo. This observation suggests that altered protein composition might affect the antiatherogenic and antiinflammatory properties of HDL. We hypothesized that an intervention that… CONTINUE READING

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