Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia.


Both sphingosine and sphingosine-1-phosphate (S1P) were able to protect the ex vivo rat heart from ischemia reperfusion injury when added to the perfusion medium at the time of reperfusion after a 40min ischemia (postconditioning). Inhibitor studies revealed distinct mechanisms of protection, with S1P employing a G-protein coupled receptor pathway and… (More)
DOI: 10.1016/j.bbrc.2008.08.022