Combined snake venomics and venom gland transcriptomic analysis of Bothropoides pauloensis.

@article{Rodrigues2012CombinedSV,
  title={Combined snake venomics and venom gland transcriptomic analysis of Bothropoides pauloensis.},
  author={Renata Santos Rodrigues and Johara Boldrini-França and Fernando P P Fonseca and Pilar Garc{\'i}a de la Torre and Fl{\'a}vio Henrique-Silva and L Puig Sanz and Juan J Calvete and Veridiana de Melo Rodrigues},
  journal={Journal of proteomics},
  year={2012},
  volume={75 9},
  pages={2707-20}
}
Unraveling the repertoire of venom toxins of Bothropoides pauloensis was assessed by snake venomics and venom gland transcriptomic surveys. Both approaches yielded converging overall figures, pointing to metalloproteinases (~37%), PLA(2)s (26-32%), and vasoactive (bradykinin-potentiating) peptides (12-17%) as the major toxin classes. The high occurrence of SVMPs, PLA(2) molecules, vasoactive peptides, along with serine proteinases, explains the local and systemic effects observed in… CONTINUE READING
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