Combined single-molecule electrical recording and single-molecule spectroscopy studies of ion channel conformational dynamics.

Abstract

Stochastic and inhomogeneous conformational changes regulate the function and dynamics of ion channels. Such complexity makes it difficult, if not impossible, to characterize ion channel dynamics using conventional electrical recording alone since that the measurement does not specifically interrogate the associated conformational changes but rather the… (More)
DOI: 10.1016/S0091-679X(08)00819-4

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