Combined short-term immunotherapy for experimental autoimmune myasthenia gravis.

@article{Pestronk1983CombinedSI,
  title={Combined short-term immunotherapy for experimental autoimmune myasthenia gravis.},
  author={Alan Pestronk and Daniel B. Drachman and References Teoh and Robert N. Adams},
  journal={Annals of neurology},
  year={1983},
  volume={14 2},
  pages={235-41}
}
A therapeutic strategy was designed to eliminate the humoral immune response to acetylcholine receptor (AChR) in ongoing experimental autoimmune myasthenia gravis (EAMG). Rats with EAMG were treated with a protocol consisting of three components: (1) A single high dose of cyclophosphamide (200 mg/kg) was used to produce a rapid and sustained fall in the anti-AChR antibody levels by preferential destruction of antibody-producing B-lymphocytes. "Memory" lymphocytes were not eliminated by… CONTINUE READING

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