Combined sensitization of mice to extracts of dust mite, ragweed, and Aspergillus species breaks through tolerance and establishes chronic features of asthma.

@article{Goplen2009CombinedSO,
  title={Combined sensitization of mice to extracts of dust mite, ragweed, and Aspergillus species breaks through tolerance and establishes chronic features of asthma.},
  author={Nicholas P Goplen and Md Zunayet Karim and Qiaoling Liang and Magdalena M. Gorska and Sadee Rozario and Lei Guo and Rafeul Alam},
  journal={The Journal of allergy and clinical immunology},
  year={2009},
  volume={123 4},
  pages={925-32.e11}
}
BACKGROUND Existing asthma models develop tolerance when chronically exposed to the same allergen. OBJECTIVE We sought to establish a chronic model that sustains features of asthma long after discontinuation of allergen exposure. METHODS We immunized and exposed mice to a combination of single, double, or triple allergens (dust mite, ragweed, and Aspergillus species) intranasally for 8 weeks. Airway hyperreactivity (AHR) and morphologic features of asthma were studied 3 weeks after allergen… CONTINUE READING
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