Combined roles of loops C and D in the interactions of a neonicotinoid insecticide imidacloprid with the α4β2 nicotinic acetylcholine receptor

@article{Toshima2009CombinedRO,
  title={Combined roles of loops C and D in the interactions of a neonicotinoid insecticide imidacloprid with the α4β2 nicotinic acetylcholine receptor},
  author={Kayoko Toshima and Satoshi Kanaoka and Atsushi Yamada and Kiyoshi Tarumoto and Kazuhiko Matsuda},
  journal={Neuropharmacology},
  year={2009},
  volume={56},
  pages={264-272}
}
Neonicotinoid insecticides are widely used for crop protection based on their selective actions on insect nicotinic acetylcholine receptors (insect nAChRs). Loops C and D in insect nAChRs have been shown to possess structural features favorable for neonicotinoid-nAChR interactions. However, it remains to be resolved whether such features serve either co-operatively, or independently, to enhance neonicotinoid sensitivity of nAChRs. We therefore examined using voltage-clamp electrophysiology the… CONTINUE READING
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