Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive women.

@article{Hesselink2011CombinedPM,
  title={Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive women.},
  author={Albertus Theodorus Hesselink and Dani{\"e}lle A M Heideman and Renske D. M. Steenbergen and Veerle M. H. Coup{\'e} and Ren{\'e}e M Overmeer and Dorien C Rijkaart and Johannes Berkhof and Chris J L M Meijer and Peter J. F. Snijders},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 8},
  pages={2459-65}
}
PURPOSE Screening women for high-grade cervical intraepithelial neoplasia or cervical cancer (CIN3(+)) by high-risk human papillomavirus (hrHPV) testing has as side-effect the detection of hrHPV-positive women without clinically relevant lesions. Here, we developed an objective assay assessing the methylation status of the promoter regions of CADM1 and MAL to triage hrHPV-positive women for CIN3(+). EXPERIMENTAL DESIGN In a training set (51 women with CIN3(+) and 224 without CIN2(+)), panels… CONTINUE READING

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