Combined procoagulant activity and proteolytic activity of acute promyelocytic leukemic cells: reversal of the bleeding disorder by cell differentiation.

@article{Wijermans1989CombinedPA,
  title={Combined procoagulant activity and proteolytic activity of acute promyelocytic leukemic cells: reversal of the bleeding disorder by cell differentiation.},
  author={Pierre W. Wijermans and Vivienne I. Rebel and Gert Jan Ossenkoppele and Peter C. Huijgens and M M Langenhuijsen},
  journal={Blood},
  year={1989},
  volume={73 3},
  pages={
          800-5
        }
}
In the human promyelocytic cell line HL60, we observed both a strong procoagulant activity (PCA) on the cell membrane and proteolytic activity in the lysate of these cells. Because these cell-line cells are susceptible to differentiation to either a more mature granulocytic or monocytic form, we were able to study the hypothesis that the combination of PCA and proteolytic activity is confined to the promyelocyte. This may explain the severe coagulopathy seen in patients with acute promyelocytic… CONTINUE READING

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