Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes

@article{Decochez2005CombinedPF,
  title={Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes},
  author={Katelijn Decochez and Inge Truyen and Bart Van der Auwera and Ilse Weets and Evy Vandemeulebroucke and I. H. De Leeuw and Bart Keymeulen and Chantal Mathieu and Raoul Rottiers and Daniel G Pipeleers and Frans K. Gorus and Belgian Diabetes Registry},
  journal={Diabetologia},
  year={2005},
  volume={48},
  pages={687-694}
}
Aims/hypothesisPrevention trials in first-degree relatives of type 1 diabetic patients are hampered by large interindividual differences in progression rate to diabetes. We investigated whether specific combinations of immune and genetic markers can identify subgroups with more homogeneous progression to clinical onset.MethodsAntibodies against islet cell cytoplasm (ICA), insulin (IAA), glutamate decarboxylase (GADA) and IA-2 protein (IA-2A) were measured in 790 non-diabetic control subjects… CONTINUE READING
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Citations

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Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives

  • Diabetologia
  • 2007
VIEW 7 EXCERPTS
CITES METHODS, BACKGROUND & RESULTS
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