Combined physical and chemical immobilization of glucose oxidase in alginate microspheres improves stability of encapsulation and activity.

@article{Zhu2005CombinedPA,
  title={Combined physical and chemical immobilization of glucose oxidase in alginate microspheres improves stability of encapsulation and activity.},
  author={Huiguang Zhu and Rohit Srivastava and Jonathan Brown and Michael J. McShane},
  journal={Bioconjugate chemistry},
  year={2005},
  volume={16 6},
  pages={1451-8}
}
Chemical sensors utilizing immobilized enzymes and proteins are important for monitoring chemical processes and biological systems. In this study, calcium-cross-linked alginate hydrogel microspheres were fabricated as enzyme carriers by an emulsification technique. Glucose oxidase (GOx) was encapsulated in alginate microspheres using three different methods: physical entrapment (emulsion), chemical conjugation (conjugation), and a combination of physical entrapment and chemical conjugation… CONTINUE READING

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