Combined oral carcinogenicity of HPV-16 and benzo(a)pyrene: an in vitro multistep carcinogenesis model.

@article{Park1995CombinedOC,
  title={Combined oral carcinogenicity of HPV-16 and benzo(a)pyrene: an in vitro multistep carcinogenesis model.},
  author={Noh Hyuck Park and Chandrasekhar Gujuluva and Jeong Hwa Baek and Henry M. Cherrick and Kyung Hwa Shin and Byoung Mun Min},
  journal={Oncogene},
  year={1995},
  volume={10 11},
  pages={
          2145-53
        }
}
We previously immortalized normal human oral keratinocytes by transfection with recombinant HPV-16 DNA and subsequently exposed the cells to benzo(a)pyrene for 7 days. The exposure to benzo(a)pyrene modified the immortalized cells: the modified cells (HOK-16B-BaP) proliferated in an ordinary culture medium containing physiological calcium level (1.5 mM), but demonstrated only enhanced proliferation capacity without tumor formation in nude mice and failed to show in vitro anchorage-independency… CONTINUE READING

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