Combined oral/nasal immunization protects mice from Sendai virus infection.

  title={Combined oral/nasal immunization protects mice from Sendai virus infection.},
  author={John G. Nedrud and Xaiowu Liang and Nigel Hague and Michael Lamm},
  journal={Journal of immunology},
  volume={139 10},
Based on the concept of a common mucosal immune system wherein mucosal associated lymphocytes traffic among the various mucous membranes, the murine gastrointestinal tract was immunized with Sendai virus antigens in order to elicit a virus-specific immune response in the respiratory tract. Multiple intragastric (oral) administration of live or killed Sendai virus induced IgA and IgG antiviral antibodies in both gastrointestinal secretions and serum. When cholera toxin as an adjuvant was… CONTINUE READING


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