Combined optical and electrical stimulation of neural tissue in vivo.

  title={Combined optical and electrical stimulation of neural tissue in vivo.},
  author={Austin R. Duke and Jonathan M. Cayce and Jonathan D. Malphrus and Peter Konrad and Anita Mahadevan-Jansen and E. Duco Jansen},
  journal={Journal of biomedical optics},
  volume={14 6},
Low-intensity, pulsed infrared light provides a novel nerve stimulation modality that avoids the limitations of traditional electrical methods such as necessity of contact, presence of a stimulation artifact, and relatively poor spatial precision. Infrared neural stimulation (INS) is, however, limited by a 2:1 ratio of threshold radiant exposures for damage to that for stimulation. We have shown that this ratio is increased to nearly 6:1 by combining the infrared pulse with a subthreshold… CONTINUE READING

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