Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias

@inproceedings{Rocquain2010CombinedMO,
  title={Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias},
  author={Julien Rocquain and Nadine Carbuccia and Virginie Trouplin and Stephane Raynaud and Anne Murati and Meyer Nezri and Zoulika Tadrist and Sylviane Olschwang and Norbert Vey and Daniel Birnbaum and V{\'e}ronique Gelsi-Boyer and M J Mozziconacci},
  booktitle={BMC Cancer},
  year={2010}
}
Gene mutation is an important mechanism of myeloid leukemogenesis. However, the number and combination of gene mutated in myeloid malignancies is still a matter of investigation. We searched for mutations in the ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in 65 myelodysplastic syndromes (MDSs) and 64 acute myeloid leukemias (AMLs) without balanced translocation or complex karyotype. Mutations in ASXL1 and CBL were frequent in refractory anemia with excess of… CONTINUE READING
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