Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

@inproceedings{Albers2013CombinedMO,
  title={Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice},
  author={Joachim Albers and Michal Rajski and D{\'e}sir{\'e}e Sch{\"o}nenberger and Sabine Harlander and Peter Schraml and Adriana von Teichman and Strahil B. Georgiev and Peter J. Wild and Holger Moch and Wilhelm Krek and Ian J Frew},
  booktitle={EMBO molecular medicine},
  year={2013}
}
The combinations of genetic alterations that cooperate with von Hippel-Lindau (VHL) mutation to cause clear cell renal cell carcinoma (ccRCC) remain poorly understood. We show that the TP53 tumour suppressor gene is mutated in approximately 9% of human ccRCCs. Combined deletion of Vhl and Trp53 in primary mouse embryo fibroblasts causes proliferative… CONTINUE READING