Combined modality therapy with bleomycin, hyperthermia, and radiation.

@article{Teicher1988CombinedMT,
  title={Combined modality therapy with bleomycin, hyperthermia, and radiation.},
  author={Beverly A. Teicher and Terence S. Herman and Sylvia A. Holden},
  journal={Cancer research},
  year={1988},
  volume={48 22},
  pages={
          6291-7
        }
}
In an attempt to develop better combination therapies for use with local radiation, the interaction between bleomycin and hyperthermia +/- radiation was studied in the FSaIIC tumor system. In cells exposed in vitro to bleomycin at 37 degrees C and at pH 7.40, the drug was substantially more toxic toward normally oxygenated than hypoxic cells. At hyperthermic temperatures (42 degrees or 43 degrees C), however, the differential killing between the normally oxygenated and hypoxic cells disappeared… CONTINUE READING

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