Combined-modality therapy of locally advanced cervical cancer.

  title={Combined-modality therapy of locally advanced cervical cancer.},
  author={Peter G Rose},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={21 10 Suppl},
  • Peter G Rose
  • Published 2003 in
    Journal of clinical oncology : official journal…
Six randomized trials of chemoradiotherapy in cervical cancer have demonstrated improvement with cisplatin-based chemoradiotherapy compared with radiation alone or radiation with hydroxyurea. Only one randomized trial (Gynecologic Oncology Group [GOG] 120) compared different cisplatin-based regimens and demonstrated significantly more hematologic and gastrointestinal toxic effects with the combination of cisplatin, fluorouracil, and hydroxyurea than with weekly cisplatin alone. The use of… CONTINUE READING


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