Combined microscale mechanical topography and chemical patterns on polymer cell culture substrates.

@article{Charest2006CombinedMM,
  title={Combined microscale mechanical topography and chemical patterns on polymer cell culture substrates.},
  author={Joseph L Charest and Marcus Todd Eliason and Andr{\'e}s J Garc{\'i}a and William P. King},
  journal={Biomaterials},
  year={2006},
  volume={27 11},
  pages={
          2487-94
        }
}
This paper presents a technique to independently form mechanical topography and surface chemical patterns on polymer cell substrates, and studies the response of osteoblast cells to these surface patterns. The patterns were formed in two separate steps: hot embossing imprint lithography formed the mechanical topography and microcontact printing created the chemical pattern. The resulting substrate had surface features consisting of embossed grooves 4 microm deep and 8 microm wide spaced by 16… CONTINUE READING
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