Combined microsatellite instability and BRAF gene status as biomarkers for adjuvant chemotherapy in stage III colorectal cancer.

@article{Ooki2014CombinedMI,
  title={Combined microsatellite instability and BRAF gene status as biomarkers for adjuvant chemotherapy in stage III colorectal cancer.},
  author={Akira Ooki and Kiwamu Akagi and Toshimasa Yatsuoka and Masako Asayama and Hiroki Hara and Akemi Takahashi and Miho Kakuta and Yoji Nishimura and Kensei Yamaguchi},
  journal={Journal of surgical oncology},
  year={2014},
  volume={110 8},
  pages={982-8}
}
BACKGROUND The clinical relevance of combined microsatellite instability (MSI) and BRAF status for adjuvant treatment in stage III colorectal cancer (CRC) remains elusive. METHODS In 405 patients with curatively resected stage III CRC, the prognostic value of combined MSI and BRAF status was assessed in four groups, as follows: high-levels of microsatellite instability (MSI-H) and BRAF-wild type, MSI-H and BRAF-mutation, microsatellite stable (MSS) and BRAF-wild type, and MSS and BRAF… CONTINUE READING
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