Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse.

@article{Paterniti1983CombinedLD,
  title={Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse.},
  author={James R. Paterniti and William Virgil Brown and Henry N. Ginsberg and Karen Artzt},
  journal={Science},
  year={1983},
  volume={221 4606},
  pages={
          167-9
        }
}
Two triglyceride lipases, lipoprotein lipase and hepatic triglyceride lipase, participate in the metabolism of plasma lipoproteins. A single recessive mutation, cld, on mouse chromosome 17 causes an apparent deficiency of both lipoprotein lipase and hepatic triglyceride lipase activities. Mice homozygous for this defect develop lethal hyperchylomicronemia within 2 days postpartum as a consequence of nursing. Plasma triglyceride values in affected mice often reach 20,000 milligrams per deciliter… CONTINUE READING

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