Combined linkage and association tests in mx.

@article{Posthuma2004CombinedLA,
  title={Combined linkage and association tests in mx.},
  author={Danielle Posthuma and Eco J. C. de Geus and Dorret I. Boomsma and Mike Neale},
  journal={Behavior genetics},
  year={2004},
  volume={34 2},
  pages={179-96}
}
Statistical methods aimed at the detection of genes for quantitative traits suffer from two problems: (i) when a linkage approach is employed, relatively large sample sizes are usually required; and (ii) when an association approach is employed, effects of population stratification may blur genuine locus-trait associations. The variance components method proposed by Fulker et al. (1999) addressed both these problems; it is statistically powerful because it involves a combined analysis of… CONTINUE READING

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