Combined ketogenic diet and vagus nerve stimulation: rational polytherapy?

  title={Combined ketogenic diet and vagus nerve stimulation: rational polytherapy?},
  author={Eric Heath Kossoff and Paula L. Pyzik and James E. Rubenstein and A G Christina Bergqvist and Jeffrey Buchhalter and Elizabeth J. Donner and D R Nordli and James W. Wheless},
  volume={48 1},
OBJECTIVE The concept of "rational polypharmacy" has been associated with anticonvulsant management for decades, but the term has not been applied to nonpharmacologic therapies. METHODS We conducted a multicenter, retrospective study of children who received concurrent diet (ketogenic or modified Atkins) and vagus nerve stimulation (VNS) treatment for medically intractable epilepsy. RESULTS Thirty children in total from six epilepsy centers were treated over a 6-yr period. The median age at… CONTINUE READING

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