Combined intramyocardial delivery of human pericytes and cardiac stem cells additively improves the healing of mouse infarcted hearts through stimulation of vascular and muscular repair.

@article{Avolio2015CombinedID,
  title={Combined intramyocardial delivery of human pericytes and cardiac stem cells additively improves the healing of mouse infarcted hearts through stimulation of vascular and muscular repair.},
  author={Elisa Avolio and Marco M. Meloni and Helen L. Spencer and Federica Riu and Rajesh G Katare and Giuseppe Mangialardi and Atsuhiko Oikawa and Iker Rodriguez-Arabaolaza and Zexu Dang and Kathryn J Mitchell and C. Catherine Reni and Valeria Vincenza Alvino and Jonathan Rowlinson and Ugolini Livi and Daniela Cesselli and Gianni Angelini and Costanza Emanueli and Antonio Paolo Beltrami and Paolo Madeddu},
  journal={Circulation research},
  year={2015},
  volume={116 10},
  pages={e81-94}
}
RATIONALE Optimization of cell therapy for cardiac repair may require the association of different cell populations with complementary activities. OBJECTIVE Compare the reparative potential of saphenous vein-derived pericytes (SVPs) with that of cardiac stem cells (CSCs) in a model of myocardial infarction, and investigate whether combined cell transplantation provides further improvements. METHODS AND RESULTS SVPs and CSCs were isolated from vein leftovers of coronary artery bypass graft… CONTINUE READING