Combined intoxication with methylone and 5-MeO-MIPT

@article{Shimizu2007CombinedIW,
  title={Combined intoxication with methylone and 5-MeO-MIPT},
  author={Eiji Shimizu and Hiroyuki Watanabe and Takashi Kojima and Hiroko Hagiwara and Mihisa Fujisaki and Ryosuke Miyatake and Kenji Hashimoto and Masaomi Iyo},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2007},
  volume={31},
  pages={288-291}
}

New Psychoactive Substance 5-MeO-MIPT In vivo Acute Toxicity and Hystotoxicological Study.

TLDR
Low-dose 5-MeO-MiPT did not cause any serious histopathological effects on the liver, kidney, and brain, and high doses induce apoptotic cell death through caspase activity.

Methylone and Monoamine Transporters: Correlation with Toxicity

TLDR
The ability of methylone to inhibit monoamine transporter function, probably by acting as a transportable substrate, underlies the synergistic effect of methyl one and methamphetamine.

Distribution of methylone in four postmortem cases.

TLDR
Analysis of several tissue samples shows that methylone does not sequester in a particular tissue type after death, and two different extraction methods, as well as analysis of derivatized and underivatized methylone, show that the drug is suitable for analysis in either method.

Sudden Cardiac Death Associated With Methylone Use

TLDR
This report reports a case of sudden death related to the synthetic cathinone methylone (3,4-methylenedioxy-N-methylcathinonmethylone) in a previously healthy 19-year-old man, and suggests that methylone toxicity has been greatly underestimated by users of this synthetic cathine.

ACtIvIty AnD BIOtRAnSFORmAtIOn OF tHREE SyntHEtIC “ LEGAL HIGHS ” : mEPHEDROnE , mEtHyLOnE AnD 3 , 4-mEtHyLEnODIOxyPyROvALEROnE

TLDR
The affinity of these substances for receptors, and also their pathways of biotransformation have been analysed, indicating the main metabolites that can be detected in humans after ingestion of the above mentioned synthetic “legal highs”.

Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters.

TLDR
Data indicate that DAT, but not SERT, is strongly associated with the lethal toxicity produced by methylone, which did not seem to be dependent on the hyperthermic effects of methylone.

Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography–mass spectrometry

TLDR
The STA procedure allowed the detection of mephedrone, butylone, methylone, and their metabolites in urine of rats treated with doses corresponding to those reported for abuse of amphetamines and should be suitable for proof of an intake of the bk-designer drugs in human urine.

Metabolism of the tryptamine-derived new psychoactive substances 5-MeO-2-Me-DALT, 5-MeO-2-Me-ALCHT, and 5-MeO-2-Me-DIPT and their detectability in urine studied by GC-MS, LC-MSn , and LC-HR-MS/MS.

TLDR
The aims of the presented work were to study the phase I and II metabolism and the detectability in standard urine screening approaches of 5-methoxy-2-methyl-N,N-diallyltryptamine, and to confirm that the main metabolic reactions in humans and rats might be identical.
...

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Recently, two new ecstasy‐like substances, methylone and mCPP, were found in street drugs in the Netherlands by the Drugs Information and Monitoring System (DIMS). Methylone

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TLDR
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