Combined inhibition of interleukin-1 and tumor necrosis factor in rodent endotoxemia: improved survival and organ function.

@article{Russell1995CombinedIO,
  title={Combined inhibition of interleukin-1 and tumor necrosis factor in rodent endotoxemia: improved survival and organ function.},
  author={D. A. Russell and Kean Govemor Robert K. Tucker and Narumol Chinookoswong and Robert A. Thompson and Tadahiko Kohno},
  journal={The Journal of infectious diseases},
  year={1995},
  volume={171 6},
  pages={1528-38}
}
The interleukin (IL)-1 receptor antagonist (Ra) and a polyethylene glycol-linked dimer of the type I soluble receptor of tumor necrosis factor (TNF), PEG-(rsTNF-RI)2, were used to determine whether maximal protection against lethality and organ dysfunction is achieved by single or dual cytokine inhibition under rigorous conditions of rodent endotoxemia. Inhibition of IL-1 or TNF alone protected maximally against lethality when inhibitors were given simultaneously with lipopolysaccharide (LPS… CONTINUE READING

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