Combined inhibition of complement and CD14 efficiently attenuated the inflammatory response induced by Staphylococcus aureus in a human whole blood model.

@article{Skjeflo2014CombinedIO,
  title={Combined inhibition of complement and CD14 efficiently attenuated the inflammatory response induced by Staphylococcus aureus in a human whole blood model.},
  author={Espen Waage Skjeflo and Dorte Bang Christiansen and Terje Espevik and Erik Waage Nielsen and Tom Eirik Mollnes},
  journal={Journal of immunology},
  year={2014},
  volume={192 6},
  pages={
          2857-64
        }
}
The complement and TLR systems are activated in sepsis, contributing to an unfavorable inflammatory "storm." Combined inhibition of these systems has been documented to efficiently attenuate the inflammatory responses induced by Gram-negative bacteria. In this study, we hypothesized that the combined inhibition would attenuate the inflammatory responses induced by Gram-positive bacteria. Staphylococcus aureus bacteria (strains Cowan and Wood), as well as S. aureus cell wall lipoteichoic acid… CONTINUE READING
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