Combined immunotherapy of breast cancer with EGF and VEGF vaccines from DNA shuffling in a mouse model.


AIM Development of EGF and VEGF vaccines with high antigenicity for combined immunotherapy of EGF-EGFR signaling-dependent epithelial tumors such as breast cancer. METHOD EGF genes from mouse, human and chicken were randomly assembled to chimeric genes by DNA shuffling, then a chimeric EGF was selected out by PCR, SDS-PAGE and immunization for combined… (More)
DOI: 10.2217/imt-2017-0004

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