Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.

@article{Ali2005CombinedIA,
  title={Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.},
  author={Sumia Ali and Gwendalyn D. King and James F Curtin and Marianela Candolfi and Weidong Xiong and Chun-yan Liu and Mariana Puntel and Queng Cheng and Jes{\'u}s Prieto and Antoni Ribas and Jerzy W. Kupiec-Weglinski and Nico van Rooijen and Hans Lassmann and Pedro Ricardo Lowenstein and Maria Graciela Castro},
  journal={Cancer research},
  year={2005},
  volume={65 16},
  pages={7194-204}
}
In spite of preclinical efficacy and recent randomized, controlled studies with adenoviral vectors expressing herpes simplex virus-1 thymidine kinase (HSV1-TK) showing statistically significant increases in survival, most clinical trials using single therapies have failed to provide major therapeutic breakthroughs. Because glioma is a disease with dismal prognosis and rapid progression, it is an attractive target for gene therapy. Preclinical models using microscopic brain tumor models (e.g… CONTINUE READING

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