Combined immunophenotyping and DNA in situ hybridization to study lineage involvement in patients with myelodysplastic syndromes.

@article{Kibbelaar1992CombinedIA,
  title={Combined immunophenotyping and DNA in situ hybridization to study lineage involvement in patients with myelodysplastic syndromes.},
  author={Robby E. Kibbelaar and H V van Kamp and Enno J. Dreef and Godelieve M J S de Groot-Swings and Johanna C Kluin-Nelemans and Geoffrey C. Beverstock and Willem E. Fibbe and Philip M. Kluin},
  journal={Blood},
  year={1992},
  volume={79 7},
  pages={1823-8}
}
Clonality of myeloid and lymphoid cell fractions obtained from peripheral blood (PB) or bone marrow (BM) of five patients with a myelodysplastic syndrome (MDS), was studied by combined immunophenotypic analysis and DNA in situ hybridization. This novel technique enables quantitative and direct analysis of cytogenetic alterations in nondividing cells of distinct cell lineages. Four patients with a trisomy 8 and one patient with a translocation (1;7) were studied. For cell lineage determination… CONTINUE READING

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