Combined immunohistochemistry for thyroid peroxidase, galectin-3, CK19 and HBME-1 in differential diagnosis of thyroid tumors.

@article{Paunovic2012CombinedIF,
  title={Combined immunohistochemistry for thyroid peroxidase, galectin-3, CK19 and HBME-1 in differential diagnosis of thyroid tumors.},
  author={Ivan Paunovic and Tijana I{\vs}i{\'c} and Marija J Havelka and Svetislav B. Tati{\'c} and Dubravka Cveji{\'c} and Svetlana B. Savin},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={2012},
  volume={120 5},
  pages={368-79}
}
We evaluated some proposed molecular thyroid tumor markers: thyroid peroxidase (TPO), galectin-3, cytokeratin-19, and HBME-1, individually and in combination, by immunohistochemistry in a total of 242 archival thyroid tissue sections. The expression of each individual marker was most helpful for the diagnosis of papillary carcinoma and its follicular variant. However, none of them was sensitive and specific enough to discriminate between Hürthle adenoma and carcinoma. Galectin-3 and HBME-1… CONTINUE READING