Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors

@inproceedings{Ungerbck2015CombinedHL,
  title={Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors},
  author={Jonas Ungerb{\"a}ck and Josefine {\AA}hsberg and Tobias Strid and Rajesh Somasundaram and Mikael Sigvardsson},
  booktitle={The Journal of experimental medicine},
  year={2015}
}
To investigate how transcription factor levels impact B-lymphocyte development, we generated mice carrying transheterozygous mutations in the Pax5 and Ebf1 genes. Whereas combined reduction of Pax5 and Ebf1 had minimal impact on the development of the earliest CD19(+) progenitors, these cells displayed an increased T cell potential in vivo and in vitro. The alteration in lineage fate depended on a Notch1-mediated conversion process, whereas no signs of de-differentiation could be detected. The… CONTINUE READING
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