Combined hepatocyte-selective and blood-pool contrast agents for the CT detection of experimental liver tumors in rabbits.

@article{Weichert2000CombinedHA,
  title={Combined hepatocyte-selective and blood-pool contrast agents for the CT detection of experimental liver tumors in rabbits.},
  author={Jamey P. Weichert and Fred T. Lee and Susan G Chosy and Marc A. Longino and Janet E. Kuhlman and Dennis M. Heisey and Glen Leverson},
  journal={Radiology},
  year={2000},
  volume={216 3},
  pages={865-71}
}
PURPOSE To determine the imaging characteristics of a new computed tomographic (CT) contrast material with both hepatocyte-selective and blood-pool components (iodinated triglyceride (ITG)-dual) versus standard iohexol. MATERIALS AND METHODS VX2 carcinoma was inoculated in seven rabbits. Animals underwent nonenhanced, iohexol-enhanced (600 mg of iodine per kilogram of body weight), and ITG-dual-enhanced (blood-pool moiety, 100 mg of iodine per kilogram; hepatocyte-selective moiety, 100 or 200… CONTINUE READING

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