Combined gossypol and zoledronic acid treatment results in synergistic induction of cell death and regulates angiogenic molecules in ovarian cancer cells.

@article{Atmaca2009CombinedGA,
  title={Combined gossypol and zoledronic acid treatment results in synergistic induction of cell death and regulates angiogenic molecules in ovarian cancer cells.},
  author={H. Atmaca and G. Gorumlu and B. Karaca and M. Degirmenci and D. Tunali and Y. Cirak and D. U. Purcu and S. Uzunoğlu and B. Karabulut and U. Sanli and R. Uslu},
  journal={European cytokine network},
  year={2009},
  volume={20 3},
  pages={
          121-30
        }
}
In the present study, we aimed to evaluate the possible synergistic, cytotoxic effects of combination treatment of gossypol and zoledronic acid, in human ovarian cancer cell lines, OVCAR-3 and MDAH-2774, and to elucidate the role of this novel combination treatment on angiogenesis-related molecules in ovarian cancer. The XTT cell viability assay was used for showing cytotoxicity. Both DNA fragmentation by ELISA assay and caspase 3/7 activity measurement were used for demonstrating apoptosis. To… Expand
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