Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity.

@article{Simon2000CombinedGM,
  title={Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity.},
  author={Tabassome Simon and Laurent Becquemont and Murielle Mary-Krause and Isabelle de Waziers and Philippe H. Beaune and Christian Funck-Brentano and P. Jaillon},
  journal={Clinical pharmacology and therapeutics},
  year={2000},
  volume={67 4},
  pages={432-7}
}
BACKGROUND Glutathione conjugation of tacrine reactive metabolites depends in part on the activity of glutathione-S-transferases (GST), of which two isozymes (GST M1 and GST T1) are polymorphically expressed. OBJECTIVE AND METHODS To determine whether GST M1, GST T1, and the combined GST M1 and GST T1 null genotypes predict individual susceptibility to tacrine hepatotoxicity, 141 patients with mild to moderate Alzheimer's disease treated with tacrine were genotyped. RESULTS During the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Similar Papers

Loading similar papers…