Combined glucosamine and chondroitin sulfate provides functional and structural benefit in the anterior cruciate ligament transection model

@article{Silva2008CombinedGA,
  title={Combined glucosamine and chondroitin sulfate provides functional and structural benefit in the anterior cruciate ligament transection model},
  author={Francisco Saraiva Silva and Natalino Hajime Yoshinari and Rondinelle Ribeiro Castro and Virg{\'i}nia Claudia Carneiro Gir{\~a}o and Margarida Maria Lima Pompeu and Judith Pessoa Andrade Feitosa and Francisco Airton Castro Rocha},
  journal={Clinical Rheumatology},
  year={2008},
  volume={28},
  pages={109-117}
}
Evidence that combined glucosamine sulfate and chondroitin sulfate (Gluchon) or isolated glucosamine (Glu) modifies joint damage in osteoarthritis (OA) is still lacking. We studied joint pain and cartilage damage using the anterior cruciate ligament transection (ACLT) model. Wistar rats were subjected to ACLT of the right knee (OA) or sham operation. Groups received either Glu (500 mg/kg), Gluchon (500 mg/kg glucosamine +400 mg/kg chondroitin) or vehicle (non-treated—NT) per os starting 7 days… Expand
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