Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5.

@article{Coughlan2012CombinedFM,
  title={Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5.},
  author={Lynda Coughlan and Sabari Vallath and Alena Gros and Marta Gim{\'e}nez-Alejandre and Nico van Rooijen and Gareth J Thomas and Andrew H. Baker and Manel Cascall{\'o} and Ramon Alemany and Ian R. Hart},
  journal={Human gene therapy},
  year={2012},
  volume={23 9},
  pages={960-79}
}
Achieving high-efficiency tumor targeting after systemic delivery is a considerable challenge facing oncolytic gene therapists. Efficient retargeting should be combined with efforts to improve in vivo safety, reduce hepatotoxicity, minimize off-target interactions, and improve antitumoral potency and efficacy. We previously described the successful retargeting of adenovirus serotype 5 (Ad5) to α(v)β(6), an integrin that is highly overexpressed in numerous human carcinomas. In this study, we… CONTINUE READING
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Biodis - tribution and retargeting of FXbinding ablated adenovirus serotype 5 vectors

  • R. Alba, A. C. Bradshaw, L. Coughlan
  • Blood
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